FHIR Server FHIR Server Version n/a

{
  "resourceType" : "StructureDefinition",
  "id" : "oncology-BreastCancerStageTopic-model",
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n  <p><b>BC BreastCancerStageTopic Logical Model</b></p>\n  <p>The topic class for describing a breast cancer staging observation.</p>\n</div>"
  },
  "url" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/oncology-BreastCancerStageTopic-model",
  "identifier" : [
    {
      "system" : "http://hl7.org/fhir/us/breastcancer",
      "value" : "oncology.BreastCancerStageTopic"
    }
  ],
  "version" : "0.2.0",
  "name" : "BreastCancerStageTopicModel",
  "title" : "BC BreastCancerStageTopic Logical Model",
  "status" : "draft",
  "date" : "2018-08-17T00:00:00+10:00",
  "publisher" : "The HL7 Cancer Interoperability Group sponsored by Clinical Interoperability Council Work Group (CIC)",
  "contact" : [
    {
      "telecom" : [
        {
          "system" : "url",
          "value" : "http://www.hl7.org/Special/committees/cic/index.cfm"
        }
      ]
    }
  ],
  "description" : "The topic class for describing a breast cancer staging observation.",
  "kind" : "logical",
  "abstract" : false,
  "type" : "oncology-BreastCancerStageTopic-model",
  "baseDefinition" : "http://hl7.org/fhir/StructureDefinition/Element",
  "derivation" : "specialization",
  "snapshot" : {
    "element" : [
      {
        "id" : "oncology-BreastCancerStageTopic-model",
        "path" : "oncology-BreastCancerStageTopic-model",
        "definition" : "The topic class for describing a breast cancer staging observation.",
        "min" : 0,
        "max" : "*",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model",
          "min" : 0,
          "max" : "*"
        },
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.topicCode",
        "path" : "oncology-BreastCancerStageTopic-model.topicCode",
        "short" : "The concept representing the finding or action that is the topic of the statement.",
        "definition" : "The concept representing the finding or action that is the topic of the statement.\n\nFor action topics, the TopicCode represents the action being described. For findings, the TopicCode represents the 'question' or property being investigated. For evaluation result findings, the TopicCode contains a concept for an observable entity, such as systolic blood pressure. For assertion findings, the TopicCode contains a code representing the condition, allergy, or other item being asserted. In all cases, the TopicCode describes the topic independent of the context of the action or the finding.",
        "min" : 1,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.topicCode",
          "min" : 1,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "Coding"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.topicCode.id",
        "path" : "oncology-BreastCancerStageTopic-model.topicCode.id",
        "representation" : [
          "xmlAttr"
        ],
        "short" : "xml:id (or equivalent in JSON)",
        "definition" : "unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "Element.id",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "string"
          }
        ],
        "mapping" : [
          {
            "identity" : "rim",
            "map" : "n/a"
          }
        ]
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.topicCode.extension",
        "path" : "oncology-BreastCancerStageTopic-model.topicCode.extension",
        "slicing" : {
          "discriminator" : [
            {
              "type" : "value",
              "path" : "url"
            }
          ],
          "description" : "Extensions are always sliced by (at least) url",
          "rules" : "open"
        },
        "short" : "Additional Content defined by implementations",
        "definition" : "May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
        "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
        "min" : 0,
        "max" : "*",
        "base" : {
          "path" : "Element.extension",
          "min" : 0,
          "max" : "*"
        },
        "type" : [
          {
            "code" : "Extension"
          }
        ],
        "mapping" : [
          {
            "identity" : "rim",
            "map" : "n/a"
          }
        ]
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.topicCode.system",
        "path" : "oncology-BreastCancerStageTopic-model.topicCode.system",
        "short" : "Identity of the terminology system",
        "definition" : "The identification of the code system that defines the meaning of the symbol in the code.",
        "comment" : "The URI may be an OID (urn:oid:...) or a UUID (urn:uuid:...).  OIDs and UUIDs SHALL be references to the HL7 OID registry. Otherwise, the URI should come from HL7's list of FHIR defined special URIs or it should de-reference to some definition that establish the system clearly and unambiguously.",
        "requirements" : "Need to be unambiguous about the source of the definition of the symbol.",
        "min" : 1,
        "max" : "1",
        "base" : {
          "path" : "Coding.system",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "uri"
          }
        ],
        "fixedUri" : "http://ncimeta.nci.nih.gov",
        "isSummary" : true,
        "mapping" : [
          {
            "identity" : "v2",
            "map" : "C*E.3"
          },
          {
            "identity" : "rim",
            "map" : "./codeSystem"
          },
          {
            "identity" : "orim",
            "map" : "fhir:Coding.system rdfs:subPropertyOf dt:CDCoding.codeSystem"
          }
        ]
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.topicCode.version",
        "path" : "oncology-BreastCancerStageTopic-model.topicCode.version",
        "short" : "Version of the system - if relevant",
        "definition" : "The version of the code system which was used when choosing this code. Note that a well-maintained code system does not need the version reported, because the meaning of codes is consistent across versions. However this cannot consistently be assured. and when the meaning is not guaranteed to be consistent, the version SHOULD be exchanged.",
        "comment" : "Where the terminology does not clearly define what string should be used to identify code system versions, the recommendation is to use the date (expressed in FHIR date format) on which that version was officially published as the version date.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "Coding.version",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "string"
          }
        ],
        "isSummary" : true,
        "mapping" : [
          {
            "identity" : "v2",
            "map" : "C*E.7"
          },
          {
            "identity" : "rim",
            "map" : "./codeSystemVersion"
          },
          {
            "identity" : "orim",
            "map" : "fhir:Coding.version rdfs:subPropertyOf dt:CDCoding.codeSystemVersion"
          }
        ]
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.topicCode.code",
        "path" : "oncology-BreastCancerStageTopic-model.topicCode.code",
        "short" : "Symbol in syntax defined by the system",
        "definition" : "A symbol in syntax defined by the system. The symbol may be a predefined code or an expression in a syntax defined by the coding system (e.g. post-coordination).",
        "requirements" : "Need to refer to a particular code in the system.",
        "min" : 1,
        "max" : "1",
        "base" : {
          "path" : "Coding.code",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "code"
          }
        ],
        "fixedCode" : "C2216702",
        "isSummary" : true,
        "mapping" : [
          {
            "identity" : "v2",
            "map" : "C*E.1"
          },
          {
            "identity" : "rim",
            "map" : "./code"
          },
          {
            "identity" : "orim",
            "map" : "fhir:Coding.code rdfs:subPropertyOf dt:CDCoding.code"
          }
        ]
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.topicCode.display",
        "extension" : [
          {
            "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
            "valueBoolean" : true
          }
        ],
        "path" : "oncology-BreastCancerStageTopic-model.topicCode.display",
        "short" : "Representation defined by the system",
        "definition" : "A representation of the meaning of the code in the system, following the rules of the system.",
        "requirements" : "Need to be able to carry a human-readable meaning of the code for readers that do not know  the system.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "Coding.display",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "string"
          }
        ],
        "isSummary" : true,
        "mapping" : [
          {
            "identity" : "v2",
            "map" : "C*E.2 - but note this is not well followed"
          },
          {
            "identity" : "rim",
            "map" : "CV.displayName"
          },
          {
            "identity" : "orim",
            "map" : "fhir:Coding.display rdfs:subPropertyOf dt:CDCoding.displayName"
          }
        ]
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.topicCode.userSelected",
        "path" : "oncology-BreastCancerStageTopic-model.topicCode.userSelected",
        "short" : "If this coding was chosen directly by the user",
        "definition" : "Indicates that this coding was chosen by a user directly - i.e. off a pick list of available items (codes or displays).",
        "comment" : "Amongst a set of alternatives, a directly chosen code is the most appropriate starting point for new translations. There is some ambiguity about what exactly 'directly chosen' implies, and trading partner agreement may be needed to clarify the use of this element and its consequences more completely.",
        "requirements" : "This has been identified as a clinical safety criterium - that this exact system/code pair was chosen explicitly, rather than inferred by the system based on some rules or language processing.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "Coding.userSelected",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "boolean"
          }
        ],
        "isSummary" : true,
        "mapping" : [
          {
            "identity" : "v2",
            "map" : "Sometimes implied by being first"
          },
          {
            "identity" : "rim",
            "map" : "CD.codingRationale"
          },
          {
            "identity" : "orim",
            "map" : "fhir:Coding.userSelected fhir:mapsTo dt:CDCoding.codingRationale. fhir:Coding.userSelected fhir:hasMap fhir:Coding.userSelected.map. fhir:Coding.userSelected.map a fhir:Map;   fhir:target dt:CDCoding.codingRationale. fhir:Coding.userSelected\\#true a [     fhir:source \"true\";     fhir:target dt:CDCoding.codingRationale\\#O   ]"
          }
        ]
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.findingMethod",
        "path" : "oncology-BreastCancerStageTopic-model.findingMethod",
        "short" : "The technique used to create the finding, for example, the specific imaging technical, lab test code, or assessment vehicle.",
        "definition" : "The technique used to create the finding, for example, the specific imaging technical, lab test code, or assessment vehicle.",
        "min" : 0,
        "max" : "0",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.findingMethod",
          "min" : 0,
          "max" : "0"
        },
        "type" : [
          {
            "code" : "Coding"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false,
        "binding" : {
          "strength" : "preferred",
          "valueSetReference" : {
            "reference" : "http://loinc.org/vs"
          }
        }
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.details",
        "path" : "oncology-BreastCancerStageTopic-model.details",
        "code" : [
          {
            "system" : "http://ncimeta.nci.nih.gov",
            "code" : "C0947611"
          }
        ],
        "short" : "A text note containing additional details, explanation, description, comment, or summarization. Details can discuss, support, explain changes to, or dispute information.",
        "definition" : "A text note containing additional details, explanation, description, comment, or summarization. Details can discuss, support, explain changes to, or dispute information.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.details",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "string"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.media",
        "path" : "oncology-BreastCancerStageTopic-model.media",
        "short" : "A file that contains audio, video, image, or similar content.",
        "definition" : "A file that contains audio, video, image, or similar content.",
        "min" : 0,
        "max" : "0",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.media",
          "min" : 0,
          "max" : "0"
        },
        "type" : [
          {
            "code" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/shr-core-Media-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.category",
        "path" : "oncology-BreastCancerStageTopic-model.category",
        "short" : "A class or division of people or things having particular shared characteristics",
        "definition" : "A class or division of people or things having particular shared characteristics",
        "min" : 1,
        "max" : "*",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.category",
          "min" : 1,
          "max" : "*"
        },
        "type" : [
          {
            "code" : "Coding"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false,
        "binding" : {
          "strength" : "extensible",
          "valueSetReference" : {
            "reference" : "http://hl7.org/fhir/ValueSet/observation-category"
          }
        }
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.anatomicalLocation",
        "path" : "oncology-BreastCancerStageTopic-model.anatomicalLocation",
        "code" : [
          {
            "system" : "http://loinc.org",
            "code" : "72369-2"
          }
        ],
        "short" : "A location or structure in the body, including tissues, regions, cavities, and spaces; for example, right elbow, or left ventricle of the heart.",
        "definition" : "A location or structure in the body, including tissues, regions, cavities, and spaces; for example, right elbow, or left ventricle of the heart.",
        "min" : 0,
        "max" : "0",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.anatomicalLocation",
          "min" : 0,
          "max" : "0"
        },
        "type" : [
          {
            "code" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/cimi-element-AnatomicalLocation-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.device",
        "path" : "oncology-BreastCancerStageTopic-model.device",
        "short" : "A specific durable physical device used in diagnosis or treatment. The value is the coding for a type of device, for example, a CPAP machine. The same device might be used on multiple patients.",
        "definition" : "A specific durable physical device used in diagnosis or treatment. The value is the coding for a type of device, for example, a CPAP machine. The same device might be used on multiple patients.",
        "min" : 0,
        "max" : "0",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.device",
          "min" : 0,
          "max" : "0"
        },
        "type" : [
          {
            "code" : "Reference",
            "targetProfile" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/cimi-entity-Device-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.specimen",
        "path" : "oncology-BreastCancerStageTopic-model.specimen",
        "short" : "A specimen is a substance, physical object, or collection of objects, that the laboratory considers a single discrete, uniquely identified unit that is the subject of one or more steps in the laboratory workflow. A specimen may include multiple physical pieces as long as they are considered a single unit within the laboratory workflow. A specimen results from one to many specimen collection procedures, and may be contained in multiple specimen containers. Specimen may have one or more processing activities.",
        "definition" : "A specimen is a substance, physical object, or collection of objects, that the laboratory considers a single discrete, uniquely identified unit that is the subject of one or more steps in the laboratory workflow. A specimen may include multiple physical pieces as long as they are considered a single unit within the laboratory workflow. A specimen results from one to many specimen collection procedures, and may be contained in multiple specimen containers. Specimen may have one or more processing activities.",
        "min" : 0,
        "max" : "0",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.specimen",
          "min" : 0,
          "max" : "0"
        },
        "type" : [
          {
            "code" : "Reference",
            "targetProfile" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/cimi-entity-Specimen-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.precondition",
        "path" : "oncology-BreastCancerStageTopic-model.precondition",
        "short" : "A description of the conditions or context of an observation, for example, under sedation, fasting or post-exercise. Body position and body site are also qualifiers, but handled separately. A qualifier cannot modify the measurement type; for example, a fasting blood sugar is still a blood sugar.",
        "definition" : "A description of the conditions or context of an observation, for example, under sedation, fasting or post-exercise. Body position and body site are also qualifiers, but handled separately. A qualifier cannot modify the measurement type; for example, a fasting blood sugar is still a blood sugar.",
        "min" : 0,
        "max" : "0",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.precondition",
          "min" : 0,
          "max" : "0"
        },
        "type" : [
          {
            "code" : "Coding"
          },
          {
            "code" : "Reference",
            "targetProfile" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/cimi-statement-Observation-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.referenceRange",
        "path" : "oncology-BreastCancerStageTopic-model.referenceRange",
        "code" : [
          {
            "system" : "http://ncimeta.nci.nih.gov",
            "code" : "C0883335"
          }
        ],
        "short" : "The usual or acceptable range for a test result.",
        "definition" : "The usual or acceptable range for a test result.",
        "min" : 0,
        "max" : "0",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.referenceRange",
          "min" : 0,
          "max" : "0"
        },
        "type" : [
          {
            "code" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/cimi-topic-ReferenceRange-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.evaluationComponent",
        "path" : "oncology-BreastCancerStageTopic-model.evaluationComponent",
        "short" : "A simplified, non-separable evaluation consisting of a finding code (represented by the Concept), value (or exception value), reference range, and interpretation. The subject of the evaluation component is the same as in the parent evaluation.",
        "definition" : "A simplified, non-separable evaluation consisting of a finding code (represented by the Concept), value (or exception value), reference range, and interpretation. The subject of the evaluation component is the same as in the parent evaluation.",
        "min" : 0,
        "max" : "0",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.evaluationComponent",
          "min" : 0,
          "max" : "0"
        },
        "type" : [
          {
            "code" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/cimi-topic-EvaluationComponent-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.panelMembers",
        "path" : "oncology-BreastCancerStageTopic-model.panelMembers",
        "short" : "PanelMembers represent the elements of a group of a related but independent evaluations.",
        "definition" : "PanelMembers represent the elements of a group of a related but independent evaluations.\nExamples are the measurements that compose a complete blood count (CBC), or the elements of a pathology report. Each member is an independent evaluation, but the grouping reflects a composite lab order, shared specimen, or a single report author. Typically the Category and Reason are not given for individual findings that are part of the panel, but rather given at the level of the panel itself.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.panelMembers",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "BackboneElement"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.panelMembers.observation",
        "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation",
        "short" : "Represents the result of evaluations (measurements, tests, or questions) that have been performed.",
        "definition" : "Represents the result of evaluations (measurements, tests, or questions) that have been performed.\nObservation has a value representing the result (answer), or an ExceptionValue indicating why the value is not present. The subject of a finding can be the entire patient, or an entity such as a location body structure, intervention, or condition. Things observed about the subject can include social and behavioral factors, subjective and objective observations, and assessments.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation",
          "min" : 0,
          "max" : "1"
        },
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerPrimaryTumorClassification",
        "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerPrimaryTumorClassification",
        "code" : [
          {
            "system" : "http://snomed.info/sct",
            "code" : "78873005",
            "display" : "T category"
          }
        ],
        "short" : "The size and extent of the primary tumor, based on criteria defined by the staging system being used.",
        "definition" : "The size and extent of the primary tumor, based on criteria defined by the staging system being used.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerPrimaryTumorClassification",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "Reference",
            "targetProfile" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/oncology-BreastCancerPrimaryTumorClassification-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerRegionalNodesClassification",
        "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerRegionalNodesClassification",
        "code" : [
          {
            "system" : "http://snomed.info/sct",
            "code" : "277206009",
            "display" : "N category"
          }
        ],
        "short" : "The presence of metastases in regional lymph nodes, based on criteria defined by the staging system being used.",
        "definition" : "The presence of metastases in regional lymph nodes, based on criteria defined by the staging system being used.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerRegionalNodesClassification",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "Reference",
            "targetProfile" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/oncology-BreastCancerRegionalNodesClassification-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerDistantMetastasesClassification",
        "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerDistantMetastasesClassification",
        "code" : [
          {
            "system" : "http://snomed.info/sct",
            "code" : "277208005",
            "display" : "M category (observable entity)"
          }
        ],
        "short" : "The presence of distant metastases, based on criteria defined by the staging system being used.",
        "definition" : "The presence of distant metastases, based on criteria defined by the staging system being used.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerDistantMetastasesClassification",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "Reference",
            "targetProfile" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/oncology-BreastCancerDistantMetastasesClassification-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.hER2ReceptorStatus",
        "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.hER2ReceptorStatus",
        "code" : [
          {
            "system" : "http://loinc.org",
            "code" : "48676-1",
            "display" : "HER2 [Interpretation] in Tissue"
          }
        ],
        "short" : "HER2 receptor status. HER2 is a member of the human epidermal growth factor receptor family of proteins and is encoded by the ERBB2 oncogene. HER2 is overexpressed in 20-30% of breast tumors, and is associated with an aggressive clinical course and poor prognosis. HER2 status (positive=present or overexpressed; negative=absent) is a factor in determining prognosis and treatment options.",
        "definition" : "HER2 receptor status. HER2 is a member of the human epidermal growth factor receptor family of proteins and is encoded by the ERBB2 oncogene. HER2 is overexpressed in 20-30% of breast tumors, and is associated with an aggressive clinical course and poor prognosis. HER2 status (positive=present or overexpressed; negative=absent) is a factor in determining prognosis and treatment options.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.hER2ReceptorStatus",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "Reference",
            "targetProfile" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/oncology-HER2ReceptorStatus-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.estrogenReceptorStatus",
        "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.estrogenReceptorStatus",
        "code" : [
          {
            "system" : "http://loinc.org",
            "code" : "16112-5",
            "display" : "Estrogen receptor [Interpretation] in Tissue"
          }
        ],
        "short" : "Estrogen receptor alpha is the predominant estrogen receptor expressed in breast tissue and is overexpressed in around 50% of breast carcinomas. ER status (positive=present or overexpressed; negative=absent) is a factor in determining prognosis and treatment options.",
        "definition" : "Estrogen receptor alpha is the predominant estrogen receptor expressed in breast tissue and is overexpressed in around 50% of breast carcinomas. ER status (positive=present or overexpressed; negative=absent) is a factor in determining prognosis and treatment options.\nThe current approach is that positive/negative designation is a value, even though that value is (in fact) an interpretation of evidence (NuclearPositivity and AverageStainingIntensity).",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.estrogenReceptorStatus",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "Reference",
            "targetProfile" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/oncology-EstrogenReceptorStatus-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.progesteroneReceptorStatus",
        "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.progesteroneReceptorStatus",
        "code" : [
          {
            "system" : "http://loinc.org",
            "code" : "16113-3",
            "display" : "Progesterone receptor [Interpretation] in Tissue"
          }
        ],
        "short" : "Progesterone receptor status is a factor in determining prognosis and treatment options. The value is the percentage of cells that test (stain) positive for the presence of a receptor. The interpretation of positive or negative (found in the interpretation property) is based on the staining percentage, and may take into account the staining intensity.",
        "definition" : "Progesterone receptor status is a factor in determining prognosis and treatment options. The value is the percentage of cells that test (stain) positive for the presence of a receptor. The interpretation of positive or negative (found in the interpretation property) is based on the staining percentage, and may take into account the staining intensity.\nBased on discussion with Cancer Interoperability Group subject matter experts, there was insufficient rationale to include the following components in the data model: StainingControl, PrimaryAntibody, Allred Score (both total and component scores). We are seeking feedback on whether or not those components should be included in this model.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.progesteroneReceptorStatus",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "Reference",
            "targetProfile" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/oncology-ProgesteroneReceptorStatus-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.dCISNuclearGrade",
        "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.dCISNuclearGrade",
        "code" : [
          {
            "system" : "urn:tbd",
            "code" : "TBD",
            "display" : "Nuclear Grade"
          }
        ],
        "short" : "An evaluation of the size and shape of the nucleus in tumor cells and the percentage of tumor cells that are in the process of dividing or growing. Cancers with low nuclear grade grow and spread less quickly than cancers with high nuclear grade. In breast cancer, nuclear grade is typically evaluated for ductal carcinoma in situ (DCIS) only. There is currently no concept code for DCIS Nuclear Grade in LOINC, SNOMED, or NCI Metathesaurus.",
        "definition" : "An evaluation of the size and shape of the nucleus in tumor cells and the percentage of tumor cells that are in the process of dividing or growing. Cancers with low nuclear grade grow and spread less quickly than cancers with high nuclear grade. In breast cancer, nuclear grade is typically evaluated for ductal carcinoma in situ (DCIS) only. There is currently no concept code for DCIS Nuclear Grade in LOINC, SNOMED, or NCI Metathesaurus.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.dCISNuclearGrade",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "Reference",
            "targetProfile" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/oncology-DCISNuclearGrade-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerHistologicGrade",
        "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerHistologicGrade",
        "code" : [
          {
            "system" : "http://loinc.org",
            "code" : "44648-4",
            "display" : "Histologic grade [Score] in Breast cancer specimen Qualitative by Nottingham"
          }
        ],
        "short" : "The Elston Grade/Nottingham Score, representative of the aggressive potential of the tumor. Well differentiated cells (Grade 1) look similar to normal cells and are usually slow growing, while poorly differentiated cells (Grade 3) look very different than normal and are fast-growing.",
        "definition" : "The Elston Grade/Nottingham Score, representative of the aggressive potential of the tumor. Well differentiated cells (Grade 1) look similar to normal cells and are usually slow growing, while poorly differentiated cells (Grade 3) look very different than normal and are fast-growing.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerHistologicGrade",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "Reference",
            "targetProfile" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/oncology-BreastCancerHistologicGrade-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.stageTimingPrefix",
        "path" : "oncology-BreastCancerStageTopic-model.stageTimingPrefix",
        "code" : [
          {
            "system" : "http://snomed.info/sct",
            "code" : "260869008",
            "display" : "Timing of stage"
          }
        ],
        "short" : "Indicates when the staging was done, in terms of treatment landmarks.",
        "definition" : "Indicates when the staging was done, in terms of treatment landmarks.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.stageTimingPrefix",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "Coding"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false,
        "binding" : {
          "strength" : "required",
          "valueSetReference" : {
            "reference" : "http://hl7.org/fhir/us/breastcancer/ValueSet/oncology-StageTimingPrefixVS"
          }
        }
      }
    ]
  },
  "differential" : {
    "element" : [
      {
        "id" : "oncology-BreastCancerStageTopic-model",
        "path" : "oncology-BreastCancerStageTopic-model",
        "definition" : "The topic class for describing a breast cancer staging observation.",
        "min" : 0,
        "max" : "*",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model",
          "min" : 0,
          "max" : "*"
        },
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.topicCode",
        "path" : "oncology-BreastCancerStageTopic-model.topicCode",
        "short" : "The concept representing the finding or action that is the topic of the statement.",
        "definition" : "The concept representing the finding or action that is the topic of the statement.\n\nFor action topics, the TopicCode represents the action being described. For findings, the TopicCode represents the 'question' or property being investigated. For evaluation result findings, the TopicCode contains a concept for an observable entity, such as systolic blood pressure. For assertion findings, the TopicCode contains a code representing the condition, allergy, or other item being asserted. In all cases, the TopicCode describes the topic independent of the context of the action or the finding.",
        "min" : 1,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.topicCode",
          "min" : 1,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "Coding"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.topicCode.id",
        "path" : "oncology-BreastCancerStageTopic-model.topicCode.id",
        "representation" : [
          "xmlAttr"
        ],
        "short" : "xml:id (or equivalent in JSON)",
        "definition" : "unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "Element.id",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "string"
          }
        ],
        "mapping" : [
          {
            "identity" : "rim",
            "map" : "n/a"
          }
        ]
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.topicCode.extension",
        "path" : "oncology-BreastCancerStageTopic-model.topicCode.extension",
        "slicing" : {
          "discriminator" : [
            {
              "type" : "value",
              "path" : "url"
            }
          ],
          "description" : "Extensions are always sliced by (at least) url",
          "rules" : "open"
        },
        "short" : "Additional Content defined by implementations",
        "definition" : "May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
        "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
        "min" : 0,
        "max" : "*",
        "base" : {
          "path" : "Element.extension",
          "min" : 0,
          "max" : "*"
        },
        "type" : [
          {
            "code" : "Extension"
          }
        ],
        "mapping" : [
          {
            "identity" : "rim",
            "map" : "n/a"
          }
        ]
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.topicCode.system",
        "path" : "oncology-BreastCancerStageTopic-model.topicCode.system",
        "short" : "Identity of the terminology system",
        "definition" : "The identification of the code system that defines the meaning of the symbol in the code.",
        "comment" : "The URI may be an OID (urn:oid:...) or a UUID (urn:uuid:...).  OIDs and UUIDs SHALL be references to the HL7 OID registry. Otherwise, the URI should come from HL7's list of FHIR defined special URIs or it should de-reference to some definition that establish the system clearly and unambiguously.",
        "requirements" : "Need to be unambiguous about the source of the definition of the symbol.",
        "min" : 1,
        "max" : "1",
        "base" : {
          "path" : "Coding.system",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "uri"
          }
        ],
        "fixedUri" : "http://ncimeta.nci.nih.gov",
        "isSummary" : true,
        "mapping" : [
          {
            "identity" : "v2",
            "map" : "C*E.3"
          },
          {
            "identity" : "rim",
            "map" : "./codeSystem"
          },
          {
            "identity" : "orim",
            "map" : "fhir:Coding.system rdfs:subPropertyOf dt:CDCoding.codeSystem"
          }
        ]
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.topicCode.version",
        "path" : "oncology-BreastCancerStageTopic-model.topicCode.version",
        "short" : "Version of the system - if relevant",
        "definition" : "The version of the code system which was used when choosing this code. Note that a well-maintained code system does not need the version reported, because the meaning of codes is consistent across versions. However this cannot consistently be assured. and when the meaning is not guaranteed to be consistent, the version SHOULD be exchanged.",
        "comment" : "Where the terminology does not clearly define what string should be used to identify code system versions, the recommendation is to use the date (expressed in FHIR date format) on which that version was officially published as the version date.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "Coding.version",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "string"
          }
        ],
        "isSummary" : true,
        "mapping" : [
          {
            "identity" : "v2",
            "map" : "C*E.7"
          },
          {
            "identity" : "rim",
            "map" : "./codeSystemVersion"
          },
          {
            "identity" : "orim",
            "map" : "fhir:Coding.version rdfs:subPropertyOf dt:CDCoding.codeSystemVersion"
          }
        ]
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.topicCode.code",
        "path" : "oncology-BreastCancerStageTopic-model.topicCode.code",
        "short" : "Symbol in syntax defined by the system",
        "definition" : "A symbol in syntax defined by the system. The symbol may be a predefined code or an expression in a syntax defined by the coding system (e.g. post-coordination).",
        "requirements" : "Need to refer to a particular code in the system.",
        "min" : 1,
        "max" : "1",
        "base" : {
          "path" : "Coding.code",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "code"
          }
        ],
        "fixedCode" : "C2216702",
        "isSummary" : true,
        "mapping" : [
          {
            "identity" : "v2",
            "map" : "C*E.1"
          },
          {
            "identity" : "rim",
            "map" : "./code"
          },
          {
            "identity" : "orim",
            "map" : "fhir:Coding.code rdfs:subPropertyOf dt:CDCoding.code"
          }
        ]
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.topicCode.display",
        "extension" : [
          {
            "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
            "valueBoolean" : true
          }
        ],
        "path" : "oncology-BreastCancerStageTopic-model.topicCode.display",
        "short" : "Representation defined by the system",
        "definition" : "A representation of the meaning of the code in the system, following the rules of the system.",
        "requirements" : "Need to be able to carry a human-readable meaning of the code for readers that do not know  the system.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "Coding.display",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "string"
          }
        ],
        "isSummary" : true,
        "mapping" : [
          {
            "identity" : "v2",
            "map" : "C*E.2 - but note this is not well followed"
          },
          {
            "identity" : "rim",
            "map" : "CV.displayName"
          },
          {
            "identity" : "orim",
            "map" : "fhir:Coding.display rdfs:subPropertyOf dt:CDCoding.displayName"
          }
        ]
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.topicCode.userSelected",
        "path" : "oncology-BreastCancerStageTopic-model.topicCode.userSelected",
        "short" : "If this coding was chosen directly by the user",
        "definition" : "Indicates that this coding was chosen by a user directly - i.e. off a pick list of available items (codes or displays).",
        "comment" : "Amongst a set of alternatives, a directly chosen code is the most appropriate starting point for new translations. There is some ambiguity about what exactly 'directly chosen' implies, and trading partner agreement may be needed to clarify the use of this element and its consequences more completely.",
        "requirements" : "This has been identified as a clinical safety criterium - that this exact system/code pair was chosen explicitly, rather than inferred by the system based on some rules or language processing.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "Coding.userSelected",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "boolean"
          }
        ],
        "isSummary" : true,
        "mapping" : [
          {
            "identity" : "v2",
            "map" : "Sometimes implied by being first"
          },
          {
            "identity" : "rim",
            "map" : "CD.codingRationale"
          },
          {
            "identity" : "orim",
            "map" : "fhir:Coding.userSelected fhir:mapsTo dt:CDCoding.codingRationale. fhir:Coding.userSelected fhir:hasMap fhir:Coding.userSelected.map. fhir:Coding.userSelected.map a fhir:Map;   fhir:target dt:CDCoding.codingRationale. fhir:Coding.userSelected\\#true a [     fhir:source \"true\";     fhir:target dt:CDCoding.codingRationale\\#O   ]"
          }
        ]
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.findingMethod",
        "path" : "oncology-BreastCancerStageTopic-model.findingMethod",
        "short" : "The technique used to create the finding, for example, the specific imaging technical, lab test code, or assessment vehicle.",
        "definition" : "The technique used to create the finding, for example, the specific imaging technical, lab test code, or assessment vehicle.",
        "min" : 0,
        "max" : "0",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.findingMethod",
          "min" : 0,
          "max" : "0"
        },
        "type" : [
          {
            "code" : "Coding"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false,
        "binding" : {
          "strength" : "preferred",
          "valueSetReference" : {
            "reference" : "http://loinc.org/vs"
          }
        }
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.details",
        "path" : "oncology-BreastCancerStageTopic-model.details",
        "code" : [
          {
            "system" : "http://ncimeta.nci.nih.gov",
            "code" : "C0947611"
          }
        ],
        "short" : "A text note containing additional details, explanation, description, comment, or summarization. Details can discuss, support, explain changes to, or dispute information.",
        "definition" : "A text note containing additional details, explanation, description, comment, or summarization. Details can discuss, support, explain changes to, or dispute information.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.details",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "string"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.media",
        "path" : "oncology-BreastCancerStageTopic-model.media",
        "short" : "A file that contains audio, video, image, or similar content.",
        "definition" : "A file that contains audio, video, image, or similar content.",
        "min" : 0,
        "max" : "0",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.media",
          "min" : 0,
          "max" : "0"
        },
        "type" : [
          {
            "code" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/shr-core-Media-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.category",
        "path" : "oncology-BreastCancerStageTopic-model.category",
        "short" : "A class or division of people or things having particular shared characteristics",
        "definition" : "A class or division of people or things having particular shared characteristics",
        "min" : 1,
        "max" : "*",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.category",
          "min" : 1,
          "max" : "*"
        },
        "type" : [
          {
            "code" : "Coding"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false,
        "binding" : {
          "strength" : "extensible",
          "valueSetReference" : {
            "reference" : "http://hl7.org/fhir/ValueSet/observation-category"
          }
        }
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.anatomicalLocation",
        "path" : "oncology-BreastCancerStageTopic-model.anatomicalLocation",
        "code" : [
          {
            "system" : "http://loinc.org",
            "code" : "72369-2"
          }
        ],
        "short" : "A location or structure in the body, including tissues, regions, cavities, and spaces; for example, right elbow, or left ventricle of the heart.",
        "definition" : "A location or structure in the body, including tissues, regions, cavities, and spaces; for example, right elbow, or left ventricle of the heart.",
        "min" : 0,
        "max" : "0",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.anatomicalLocation",
          "min" : 0,
          "max" : "0"
        },
        "type" : [
          {
            "code" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/cimi-element-AnatomicalLocation-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.device",
        "path" : "oncology-BreastCancerStageTopic-model.device",
        "short" : "A specific durable physical device used in diagnosis or treatment. The value is the coding for a type of device, for example, a CPAP machine. The same device might be used on multiple patients.",
        "definition" : "A specific durable physical device used in diagnosis or treatment. The value is the coding for a type of device, for example, a CPAP machine. The same device might be used on multiple patients.",
        "min" : 0,
        "max" : "0",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.device",
          "min" : 0,
          "max" : "0"
        },
        "type" : [
          {
            "code" : "Reference",
            "targetProfile" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/cimi-entity-Device-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.specimen",
        "path" : "oncology-BreastCancerStageTopic-model.specimen",
        "short" : "A specimen is a substance, physical object, or collection of objects, that the laboratory considers a single discrete, uniquely identified unit that is the subject of one or more steps in the laboratory workflow. A specimen may include multiple physical pieces as long as they are considered a single unit within the laboratory workflow. A specimen results from one to many specimen collection procedures, and may be contained in multiple specimen containers. Specimen may have one or more processing activities.",
        "definition" : "A specimen is a substance, physical object, or collection of objects, that the laboratory considers a single discrete, uniquely identified unit that is the subject of one or more steps in the laboratory workflow. A specimen may include multiple physical pieces as long as they are considered a single unit within the laboratory workflow. A specimen results from one to many specimen collection procedures, and may be contained in multiple specimen containers. Specimen may have one or more processing activities.",
        "min" : 0,
        "max" : "0",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.specimen",
          "min" : 0,
          "max" : "0"
        },
        "type" : [
          {
            "code" : "Reference",
            "targetProfile" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/cimi-entity-Specimen-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.precondition",
        "path" : "oncology-BreastCancerStageTopic-model.precondition",
        "short" : "A description of the conditions or context of an observation, for example, under sedation, fasting or post-exercise. Body position and body site are also qualifiers, but handled separately. A qualifier cannot modify the measurement type; for example, a fasting blood sugar is still a blood sugar.",
        "definition" : "A description of the conditions or context of an observation, for example, under sedation, fasting or post-exercise. Body position and body site are also qualifiers, but handled separately. A qualifier cannot modify the measurement type; for example, a fasting blood sugar is still a blood sugar.",
        "min" : 0,
        "max" : "0",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.precondition",
          "min" : 0,
          "max" : "0"
        },
        "type" : [
          {
            "code" : "Coding"
          },
          {
            "code" : "Reference",
            "targetProfile" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/cimi-statement-Observation-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.referenceRange",
        "path" : "oncology-BreastCancerStageTopic-model.referenceRange",
        "code" : [
          {
            "system" : "http://ncimeta.nci.nih.gov",
            "code" : "C0883335"
          }
        ],
        "short" : "The usual or acceptable range for a test result.",
        "definition" : "The usual or acceptable range for a test result.",
        "min" : 0,
        "max" : "0",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.referenceRange",
          "min" : 0,
          "max" : "0"
        },
        "type" : [
          {
            "code" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/cimi-topic-ReferenceRange-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.evaluationComponent",
        "path" : "oncology-BreastCancerStageTopic-model.evaluationComponent",
        "short" : "A simplified, non-separable evaluation consisting of a finding code (represented by the Concept), value (or exception value), reference range, and interpretation. The subject of the evaluation component is the same as in the parent evaluation.",
        "definition" : "A simplified, non-separable evaluation consisting of a finding code (represented by the Concept), value (or exception value), reference range, and interpretation. The subject of the evaluation component is the same as in the parent evaluation.",
        "min" : 0,
        "max" : "0",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.evaluationComponent",
          "min" : 0,
          "max" : "0"
        },
        "type" : [
          {
            "code" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/cimi-topic-EvaluationComponent-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.panelMembers",
        "path" : "oncology-BreastCancerStageTopic-model.panelMembers",
        "short" : "PanelMembers represent the elements of a group of a related but independent evaluations.",
        "definition" : "PanelMembers represent the elements of a group of a related but independent evaluations.\nExamples are the measurements that compose a complete blood count (CBC), or the elements of a pathology report. Each member is an independent evaluation, but the grouping reflects a composite lab order, shared specimen, or a single report author. Typically the Category and Reason are not given for individual findings that are part of the panel, but rather given at the level of the panel itself.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.panelMembers",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "BackboneElement"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.panelMembers.observation",
        "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation",
        "short" : "Represents the result of evaluations (measurements, tests, or questions) that have been performed.",
        "definition" : "Represents the result of evaluations (measurements, tests, or questions) that have been performed.\nObservation has a value representing the result (answer), or an ExceptionValue indicating why the value is not present. The subject of a finding can be the entire patient, or an entity such as a location body structure, intervention, or condition. Things observed about the subject can include social and behavioral factors, subjective and objective observations, and assessments.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation",
          "min" : 0,
          "max" : "1"
        },
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerPrimaryTumorClassification",
        "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerPrimaryTumorClassification",
        "code" : [
          {
            "system" : "http://snomed.info/sct",
            "code" : "78873005",
            "display" : "T category"
          }
        ],
        "short" : "The size and extent of the primary tumor, based on criteria defined by the staging system being used.",
        "definition" : "The size and extent of the primary tumor, based on criteria defined by the staging system being used.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerPrimaryTumorClassification",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "Reference",
            "targetProfile" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/oncology-BreastCancerPrimaryTumorClassification-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerRegionalNodesClassification",
        "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerRegionalNodesClassification",
        "code" : [
          {
            "system" : "http://snomed.info/sct",
            "code" : "277206009",
            "display" : "N category"
          }
        ],
        "short" : "The presence of metastases in regional lymph nodes, based on criteria defined by the staging system being used.",
        "definition" : "The presence of metastases in regional lymph nodes, based on criteria defined by the staging system being used.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerRegionalNodesClassification",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "Reference",
            "targetProfile" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/oncology-BreastCancerRegionalNodesClassification-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerDistantMetastasesClassification",
        "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerDistantMetastasesClassification",
        "code" : [
          {
            "system" : "http://snomed.info/sct",
            "code" : "277208005",
            "display" : "M category (observable entity)"
          }
        ],
        "short" : "The presence of distant metastases, based on criteria defined by the staging system being used.",
        "definition" : "The presence of distant metastases, based on criteria defined by the staging system being used.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerDistantMetastasesClassification",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "Reference",
            "targetProfile" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/oncology-BreastCancerDistantMetastasesClassification-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.hER2ReceptorStatus",
        "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.hER2ReceptorStatus",
        "code" : [
          {
            "system" : "http://loinc.org",
            "code" : "48676-1",
            "display" : "HER2 [Interpretation] in Tissue"
          }
        ],
        "short" : "HER2 receptor status. HER2 is a member of the human epidermal growth factor receptor family of proteins and is encoded by the ERBB2 oncogene. HER2 is overexpressed in 20-30% of breast tumors, and is associated with an aggressive clinical course and poor prognosis. HER2 status (positive=present or overexpressed; negative=absent) is a factor in determining prognosis and treatment options.",
        "definition" : "HER2 receptor status. HER2 is a member of the human epidermal growth factor receptor family of proteins and is encoded by the ERBB2 oncogene. HER2 is overexpressed in 20-30% of breast tumors, and is associated with an aggressive clinical course and poor prognosis. HER2 status (positive=present or overexpressed; negative=absent) is a factor in determining prognosis and treatment options.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.hER2ReceptorStatus",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "Reference",
            "targetProfile" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/oncology-HER2ReceptorStatus-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.estrogenReceptorStatus",
        "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.estrogenReceptorStatus",
        "code" : [
          {
            "system" : "http://loinc.org",
            "code" : "16112-5",
            "display" : "Estrogen receptor [Interpretation] in Tissue"
          }
        ],
        "short" : "Estrogen receptor alpha is the predominant estrogen receptor expressed in breast tissue and is overexpressed in around 50% of breast carcinomas. ER status (positive=present or overexpressed; negative=absent) is a factor in determining prognosis and treatment options.",
        "definition" : "Estrogen receptor alpha is the predominant estrogen receptor expressed in breast tissue and is overexpressed in around 50% of breast carcinomas. ER status (positive=present or overexpressed; negative=absent) is a factor in determining prognosis and treatment options.\nThe current approach is that positive/negative designation is a value, even though that value is (in fact) an interpretation of evidence (NuclearPositivity and AverageStainingIntensity).",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.estrogenReceptorStatus",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "Reference",
            "targetProfile" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/oncology-EstrogenReceptorStatus-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.progesteroneReceptorStatus",
        "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.progesteroneReceptorStatus",
        "code" : [
          {
            "system" : "http://loinc.org",
            "code" : "16113-3",
            "display" : "Progesterone receptor [Interpretation] in Tissue"
          }
        ],
        "short" : "Progesterone receptor status is a factor in determining prognosis and treatment options. The value is the percentage of cells that test (stain) positive for the presence of a receptor. The interpretation of positive or negative (found in the interpretation property) is based on the staining percentage, and may take into account the staining intensity.",
        "definition" : "Progesterone receptor status is a factor in determining prognosis and treatment options. The value is the percentage of cells that test (stain) positive for the presence of a receptor. The interpretation of positive or negative (found in the interpretation property) is based on the staining percentage, and may take into account the staining intensity.\nBased on discussion with Cancer Interoperability Group subject matter experts, there was insufficient rationale to include the following components in the data model: StainingControl, PrimaryAntibody, Allred Score (both total and component scores). We are seeking feedback on whether or not those components should be included in this model.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.progesteroneReceptorStatus",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "Reference",
            "targetProfile" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/oncology-ProgesteroneReceptorStatus-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.dCISNuclearGrade",
        "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.dCISNuclearGrade",
        "code" : [
          {
            "system" : "urn:tbd",
            "code" : "TBD",
            "display" : "Nuclear Grade"
          }
        ],
        "short" : "An evaluation of the size and shape of the nucleus in tumor cells and the percentage of tumor cells that are in the process of dividing or growing. Cancers with low nuclear grade grow and spread less quickly than cancers with high nuclear grade. In breast cancer, nuclear grade is typically evaluated for ductal carcinoma in situ (DCIS) only. There is currently no concept code for DCIS Nuclear Grade in LOINC, SNOMED, or NCI Metathesaurus.",
        "definition" : "An evaluation of the size and shape of the nucleus in tumor cells and the percentage of tumor cells that are in the process of dividing or growing. Cancers with low nuclear grade grow and spread less quickly than cancers with high nuclear grade. In breast cancer, nuclear grade is typically evaluated for ductal carcinoma in situ (DCIS) only. There is currently no concept code for DCIS Nuclear Grade in LOINC, SNOMED, or NCI Metathesaurus.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.dCISNuclearGrade",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "Reference",
            "targetProfile" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/oncology-DCISNuclearGrade-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerHistologicGrade",
        "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerHistologicGrade",
        "code" : [
          {
            "system" : "http://loinc.org",
            "code" : "44648-4",
            "display" : "Histologic grade [Score] in Breast cancer specimen Qualitative by Nottingham"
          }
        ],
        "short" : "The Elston Grade/Nottingham Score, representative of the aggressive potential of the tumor. Well differentiated cells (Grade 1) look similar to normal cells and are usually slow growing, while poorly differentiated cells (Grade 3) look very different than normal and are fast-growing.",
        "definition" : "The Elston Grade/Nottingham Score, representative of the aggressive potential of the tumor. Well differentiated cells (Grade 1) look similar to normal cells and are usually slow growing, while poorly differentiated cells (Grade 3) look very different than normal and are fast-growing.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.panelMembers.observation.breastCancerHistologicGrade",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "Reference",
            "targetProfile" : "http://hl7.org/fhir/us/breastcancer/StructureDefinition/oncology-BreastCancerHistologicGrade-model"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false
      },
      {
        "id" : "oncology-BreastCancerStageTopic-model.stageTimingPrefix",
        "path" : "oncology-BreastCancerStageTopic-model.stageTimingPrefix",
        "code" : [
          {
            "system" : "http://snomed.info/sct",
            "code" : "260869008",
            "display" : "Timing of stage"
          }
        ],
        "short" : "Indicates when the staging was done, in terms of treatment landmarks.",
        "definition" : "Indicates when the staging was done, in terms of treatment landmarks.",
        "min" : 0,
        "max" : "1",
        "base" : {
          "path" : "oncology-BreastCancerStageTopic-model.stageTimingPrefix",
          "min" : 0,
          "max" : "1"
        },
        "type" : [
          {
            "code" : "Coding"
          }
        ],
        "mustSupport" : false,
        "isModifier" : false,
        "isSummary" : false,
        "binding" : {
          "strength" : "required",
          "valueSetReference" : {
            "reference" : "http://hl7.org/fhir/us/breastcancer/ValueSet/oncology-StageTimingPrefixVS"
          }
        }
      }
    ]
  }
}
XIG built as of ??metadata-date??. Found ??metadata-resources?? resources in ??metadata-packages?? packages.